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Hyperbaric Oxygen:
Oxygen applied at pressure greater than one atmosphere. Pressure is typically expressed as atmospheres, millimeters of mercury (mm Hg) or as pounds per square inch (psi). One atmosphere is ambient pressure at sea level, which is equivalent to 760 mm Hg., or 14.7 psi.
Systemic Hyperbaric Oxygen (HBO):
Hyperbaric oxygen administered in full body chambers. The patient breathes 100% oxygen intermittently while the pressure of the treatment chamber is increased to 2 -3 atmospheres, equivalent to 1500 – 2500 mm Hg or 30 – 45 psi.
Topical Hyperbaric Oxygen (THBO):
Oxygen applied directly to the base of an open wound at pressure slightly above atmospheric e.g. 1.03 atmospheres (22 mm Hg or 0.4 psi.).
Disposable, Topical Hyperbaric Oxygen devices:
Disposable THBO devices are designed to be used one time and discarded. (Earlier multiple use extremity chamber devices were heavy, awkward to handle and difficult to clean and disinfect, increasing the risk of cross contamination between patients, and making home care use impractical.)

PURPOSE OF TOPICAL HYPERBARIC OXYGEN THERAPY
Oxygen is required for all new cell growth. Tissue at the base of chronic or non healing wounds tends to be ischemic. Application of topical hyperbaric oxygen induces the growth of new blood vessels at the wound base. The new blood vessels allow an increased flow of oxygenated blood to the wound which begins the healing process.

As healing progresses, new granulation tissue that is exposed to hyperbaric oxygen is better vascularized. This in turn leads to higher tensile strength collagen being formed during wound healing, which reduces scarring and the risk of recidivism.

Another important benefit of hyperbaric oxygen is that it is bactericidal for anaerobic bacteria e.g. Staphylococcus aureus and E.coli.

The difference between systemic HBO and topical hyperbaric oxygen (THBO) in therapeutic approach is that systemic HBO increases blood oxygen levels. However, blood oxygen levels are normally adequate for wound healing. The problem is that oxygen delivery to the wound site can be limited by poor wound tissue vascularization.

Topical hyperbaric oxygen on the other hand delivers oxygen directly to the wound. Transcutaneous oxygen levels are increased, despite the lack of well vascularized wound tissue. In addition, because this therapy is topical and relatively low pressure, there is no systemic absorption of oxygen, and therefore no risk of pulmonary or central nervous system toxicity that can result from breathing high pressure (30 – 45 psi) oxygen in full body chambers.

Hyperbaric Oxygen Therapy (HBOT) is a procedure recognized to enhance the body’s natural healing process and supplement therapy already being received by the patient.

Hyperbaric Chamber

Oxygen is a critical element in the body being able to overcome disease and illness. Breathing pressurized air has long been recognized as the answer to the decompression sickness suffered by deep sea divers known as “the bends.”
Now HBOT has emerged as a method which can offer benefit to patients facing medical conditions complicated by loss of oxygen for any reason, compromised blood circulation, bacterial infection, immune deficiency disorders/diseases, and many other conditions.
Currently only 14 indications are approved for Hyperbaric Oxygen Therapy by the FDA in the United States.  This is less than 10% of those indications utilized Internationally, including, but not limited to, uses in select Neurological Disorders, select Immune Disorders, Pre & Post surgery, Sports Medicine, Vascular Insufficiency, Anti-Aging, Pain Management, wound healing and many additional conditions.

Hyperbaric Oxygen Therapy (HBOT) for Animals and Pets

Why Hyperbaric Oxygen Therapy (HBOT) for animals and pets? Why not HBOT for animals and pets? What’s the difference between animals/pets, and humans? Very little. We’re all mammals, or at least most pets are mammals. (I’ll exclude goldfish, snakes, salamanders, insects, turtles, and the like for the moment.) There is a general principle in veterinary medicine that if a process is found in at least a few species of mammals, it is found in all species. Imagine if this weren’t true, veterinarians would have to learn about different disease processes in cats, dogs, pigs, goats, horses, hamsters, etc. and the treatment would be different in each species. This would be unbelievably complex. Fortunately, nature doesn’t work this way. Generally, disease processes are similar across species and even larger classes of living organisms.

Hyperbaric Oxygen Therapy (HBOT) Animal Experiments

Our confirmation about the similarity of disease processes in different species can be found in the voluminous Hyperbaric Oxygen Therapy animal experiments that have been done in the past 50 years. In countless experiments, HBOT has been shown to have positive effects on basic disease processes across multiple different species. In 1999, Dr. Harch argued this at the World Federation of Neurological Societies Meeting in Copenhagen, Denmark [Harch PG. Generic inhibitory drug effect of hyperbaric oxygen therapy (HBOT) on reperfusion injury (RI). Eur J Neurol, 2000;7(Suppl 3):150]. In his presentation, he collected the studies that had been done on Hyperbaric Oxygen Therapy in acute injuries that resulted in inflammation. What he found was that regardless of whether HBOT was delivered immediately before, during, or after the injury to the animal, and regardless of the animal species used (dog, rabbit, rat, mouse, pig), or the injury model in the experiment (heart attack, stroke, the bends of the brain, carbon monoxide, cardiac arrest), the results were all the same: HBOT had a dramatic impact. What it strongly suggested was that HBOT acted like a generic drug on basic disease processes in man. Dr. Harch was using this argument to convince doctors that the application of HBOT in animals should apply to humans. For the sake of this article, Dr. Harch’s scientific paper argues for the use of HBOT across the animal spectrum. In other words, the evidence is already there to use HBOT in animals. After all, that’s where the scientific investigations began that led to many of the uses of HBOT we now have in humans.

Application of Hyperbaric Oxygen Therapy (HBOT) in Animals

So what evidence exists for the use of Hyperbaric Oxygen Therapy (HBOT) in animals? To answer this question, we need to look no further than the horse veterinary world. At the Alamo Pintado Equine Medical Center in California, veterinarian Doug Herthel pioneered the application of HBOT to horses with the use of the first horse HBOT chamber. Since 2000, Dr. Herthel has successfully applied HBOT to a variety of equine conditions. This practice has now spread to other centers in the country, most notably equine hospitals in Lexington, Kentucky where a horse HBOT unit exists in the ICU of one hospital. One of the newer applications of HBOT in this ICU is for “redback foals”, birth injured foals that are struggling to survive due to lack of blood flow and oxygen to the brain. Preliminary application of HBOT to some of these newborn horses has resulted in revival and salvage of the horse. Surprisingly, this was done to human babies in 1963 and 54% of the babies were successfully resuscitated. Unfortunately, the only way a baby can get this in the United States today is if the baby is an expensive thoroughbred horse.

Beyond horses, however, HBOT is finding much wider applications in veterinary medicine. For example, veterinarians are applying HBOT to cats and dogs with a wide range of serious infections, bone conditions, snake bites, trauma, swelling from a variety of causes, and surgical trauma, including sepsis, shock, etc. Essentially, many of the same conditions that humans are treated for with HBOT are being used with animals.

Interestingly, as mentioned above, nearly all of these applications in humans were first treated experimentally in animals. It is only appropriate that HBOT should now be applied to animals clinically. The rising application of HBOT to animal diseases has spawned a veterinary hyperbaric medical association. Hopefully, the greater application to animals will help spur additional applications to humans.